Question is will there be any difference if I wait to switch out the plugs and wires after the tune as opposed to before. Not sure that the tune has anything to do with it so I thought i would ask.
If you can, I would say to do the plugs and wires first. There is always the possibility of getting a bad one of either, and getting that sorted out will save you potentially chasing your tail finding the problem after the tune.
Also, from what I have read, spark plug tip design can have a small impact on timing, in relation to when max. cylinder pressure occurs. That could impact the timing adjustment as part of the tune.